Ebola and Africa

With the influx of African migrants into the UK courtesy of the UK Government's signing of the Sandhurst Treaty and the Marrakesh Compact now would seem an appropriate time to look at 'Ebola'.

Here is what AI has to say:

mRNA technology was used to develop some Ebola vaccine candidates. Specifically, modified mRNA-based vaccines, formulated with lipid nanoparticles, have shown promising results in preclinical studies by inducing strong immune responses and providing protection against Ebola virus infection in animal models. While these vaccines were developed prior to the COVID-19 pandemic, they haven't seen widespread use due to factors like the limited geographic distribution of Ebola outbreaks. 

Here's a more detailed explanation:

• mRNA Technology for Ebola:

  Researchers have explored mRNA vaccines as a potential approach for Ebola, leveraging the technology's ability to be quickly produced and its potential for inducing robust immune responses. 

• Lipid Nanoparticles:

  The mRNA molecules are often formulated with lipid nanoparticles (LNPs) to help deliver them effectively into cells and enhance their stability. 

• Preclinical Success:

  Studies in guinea pigs, for example, demonstrated that mRNA-based Ebola vaccines induced Ebola-specific IgG and neutralizing antibody responses and offered complete protection against lethal Ebola virus infection. 

• Ebola Vaccine Landscape:

  While mRNA technology is promising, the majority of current Ebola vaccine candidates rely on viral vectors. The rVSVΔG-ZEBOV-GP vaccine, for example, is a vectored vaccine that has been shown to be effective. 

• Future Potential:

  With the success of mRNA vaccines against COVID-19, there is renewed interest in applying this technology to other infectious diseases, including Ebola, with the potential for rapid development and adaptation to different Ebola virus species or strains. 

Now I don't know about you but I felt that the videos we've been watching since March 2020 have focused on this 'new technology' of mRNA being in the Covid 19 vaccines. Nobody has ever mentioned that the mRNA was previously included in the Ebola vaccines. 🙃.

We are now seeing huge numbers moving into the UK under the auspices of the #MarrakeshCompact.